Bulletin of the Korean Chemical Society

  • 제14권2호
  • /
  • Pages.176-178
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  • 1993
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  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis of 4-Aza-cholestane Derivatives Containing Nitrosoureido Function as Antitumor Activity

  • Kim, Jack C. (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Park, Jin Il (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Hur, Tae-Ho (Department of Chemistry, College of Natural Science, Pusan National University)
  • 발행 : 1993.04.20
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초록

A series of 4-(2-chloroethyl)nitrosocarbamoyl- and 4-methyl nitrosocarbamoyl analogs of 4-Aza-$5{\alpha}$-cholestane (5a and 5b), 4-Aza-5-cholestene (6a and 6b) were synthesized and evaluated for their inhibitory activity against the Sarcoma 180 cell. The steroidal nitrosoureas, 5a, 5b, 6a and 6b displayed modest activity in vitro.

키워드

참고문헌

  1. J. Med. Chem. v.6 T. P. Johnston;G. S. McCaleb;J. A. Montgomery
  2. J. Med. Chem. v.15 F. I. Carroll;A. Philip;J.T. Blackwell;D. J. Taylor;M. E. Wall
  3. J. Med. Chem. v.22 H-Y. P. Lam;A. Begleiter;G. J. Galdenberg;C. H. Wong
  4. Arch. Pharm. Res. v.9 J. C. Kim;S. K. Choi;S. H. Moon
  5. Yakhak Hoeji v.29 J. C. Kim;I. S. Choi;D. S. Yu;S. H. Ryu;K. H. Moon
  6. J. Org. Chem. v.26 N. J. Doorenbos;L. C. Huang
  7. J. Pharm. Sci. v.63 N. J. Doorenbos;J. C. Kim
  8. J. Med. Chem. v.9 T. P. Johnston;G. S. McCaleb;P. S. Oliger;J. A. Montgomery

피인용 문헌

  1. ChemInform Abstract: Synthesis of 4-Aza-cholestane Derivatives Containing Nitrosoureido Function as Antitumor Activity. vol.24, pp.46, 1993, https://doi.org/10.1002/chin.199346213
  2. Preparation of N'-Substituted Anilino-N-Methyl-N-Nitorsoureas as Candidate Antitumor Agents vol.17, pp.6, 1993, https://doi.org/10.1007/bf02979118
  3. Synthesis and antitumor evaluation of $\alphamethylene-\gamma-butyrolactone-linked$ to 5-substituted uracil nucleic acid bases vol.19, pp.3, 1996, https://doi.org/10.1007/bf02976897
  4. Potential Antitumor ${\alpha}$-methylene-${\gamma}$-butyrolactone-bearing nucleic acid bases. 2. synthesis of $5^I-Methyl-5^I$-[2-(5-substituted uracil-1-yl)ethyl]-$2^I-oxo-3^I$-methylenetetrahydrofur vol.20, pp.3, 1993, https://doi.org/10.1007/bf02976153
  5. Potential Antitumor $\alpha$-Methylene-$\gamma$-butyrolactone-Bearing Nucleic Acid Base. 3. Synthesis of $5^1$-Methyl-$5^1$-[(6-substituted-9H-purin-9-yl)methyl]-$2^1$-oxo-$3^1$-methylenetetrahydrofur vol.21, pp.4, 1993, https://doi.org/10.1007/bf02974643