Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지

Acute Toxicity Study of Recombinant Human Interferon ${\alpha}A$ (LBD-007) in ICR Mice

  • Kim, Hyoung-Chin (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Song, Si-Whan (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Cha, Shin-Woo (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Shin, Chun-Chul (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Ha, Chang-Su (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Han, Sang-Seop (Toxicology Research Center, Korea Research Institute of Chemical Technology)
  • Published : 1993.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The acute toxicity of a recombinant human interferon $\alpha$A (code name: LBD-007) was evaluated in both sexes of ICR mice, 5 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results, LBD-007 was not considered to induce any toxic effect on the mice in mortalities, clinical findigs, body weights and gross findings. It is suggested that LD$_{50}$ values in mice would be $>48{\times}10^8$ IU/kg in the oral, subcutaneous or intravenous routes.s.

Keywords