Acute Toxicity of DWH-01 (Ranitidine : Bismuth subcitrate : Sucralfate) in Rats

랫트에 있어서 DWH-01(Ranitidine : Bismuth subcitrate : Sucralfate)의 급성독성에 관한 연구

  • 김형식 (성균관대학교 약학대학 약학연구실) ;
  • 박선미 (성균관대학교 약학대학 약학연구실) ;
  • 변수현 (성균관대학교 약학대학 약학연구실) ;
  • 김용기 (성균관대학교 약학대학 약학연구실) ;
  • 이제원 ((주)대웅제약 생물약학 연구실) ;
  • 유영효 ((주)대웅제약 생물약학 연구실) ;
  • 이향우 (성균관대학교 약학대학 약학연구실) ;
  • 이병무 (성균관대학교 약학대학 약학연구실)
  • Published : 1993.12.01

Abstract

Acute toxicities of DWH-01 (Ranitidine : Bismuth : Sucralfate= 1.5: 2 : 6) were investigated in Sprague-Dawley rats. Seven days after oral administration of DWH-01 with different doses (10 g/kg, 5 g/kg, 2.5 g/kg, 1.25 g/kg, 0.625 g/kg), we examined numbers of deaths, general signs, weight measurement and histopathological examination for both sexes of rats. Summaried results are: 1) No deaths were occurred, 2) There were no pathological and clinical differences compared with control group, 3) No significant changes of body weights were observed, and 4) In histopathological examinations of organs and tissues, there was some hemorrhage in a lung tissue of low dose group for male and female respectively, but it was thought to be caused by environmental factor. The results suggest that toxicity of DWH-01 is low and its $LD_{50}$ is over 10 g/kg in Sprague-Dawley rats.

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