Biomolecules & Therapeutics
- 제1권2호
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- Pages.204-210
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- 1993
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
신규 세파로스포린계 항생물질 DWC-751의 흰쥐 및 생쥐 체내동태
Pharmacokinetic Study on DWC-751, a New Cephalosporin, in Rats and Mice
초록
The distribution and excretion of DWC-751, a new cephalosporin, were examined in rats and mice following a single intravenous administration. DWC-751 in plasma and urine was determined by both HPLC and microbiological assay. The plasma concentration of the drug declined biexponentially. The initial and terminal half lives of the drug were 3.0 and 28.3 min, respectively. Binding of the drug to plasma proteins was 42.3%. The distribution volume at steacly-state (