Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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In vitro Antibacterial Activity of DWC-751, n New Parenteral Cephalosporin

신규 세파로스포린 항생제 DWC-751의 in vitro 항균작용

  • 심점순 ((주)대웅제약 중앙연구소) ;
  • 최문정 ((주)대웅제약 중앙연구소) ;
  • 박남준 ((주)대웅제약 중앙연구소) ;
  • 김병오 ((주)대웅제약 중앙연구소) ;
  • 유영호 ((주)대웅제약 중앙연구소) ;
  • 최응칠 (서울대학교 약학대학)
  • Published : 1993.12.01
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Abstract

We compared in vitro antibacterial activity of DWC-751, a new parenteral cephalosporin antibiotic, with those of cefpirome (CPR), cefotaxime (CTX) and ceftazidime (CAZ). DWC-751 showed a broad antimicrobial spectrum against Gram-positive and negative bacteria. The antibacterial activity of DWC-751 against Stapylococcus aureus was equal to that of CPR and superior to those of CTX and CAZ. The activity of it against Excherichia coli was more potent than those of CPR, CTX and CAZ. Against Pseudomonas aeruginosa, DWC-751 was slightly inferior to that of CAZ and superior to those of CPR and CTX. The antibacterial activity of DWC-751 was superior to those of CPR, CTX and CAZ against clinical isolates and ofloxacin resistant strains. DWC-751 showed bactericidal action against Escherichia coli at concentrations close to the MIC and induced the formation of filament and burge and lysis of Escherichia coli in a microscopic examination.

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