한국패류학회지 (The Korean Journal of Malacology)
- 제9권2호
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- Pages.85-93
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- 1993
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- 1225-3480(pISSN)
카드뮴 (Cadmium)오염 조개 섭취가 생체장기에 미치는 연향의 실험적 연구
Experimental Study on the Effect of Cadmium Containing Shellfish by the LongTerm Intake
- 소진탁 (원광대학교 의과대학) ;
-
유일수
(원광대학교 의과대학) ;
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박현
(원광대학교 의과대학) ;
- 김숙향 (원광대학교 의과대학) ;
-
김재진
(배재대학교 생물학과) ;
-
민득영
(한양대학교 의과대학)
- Soh, Chin-Thack (Wonkwang University Medical College) ;
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Yoo, Il-Soo
(Wonkwang University Medical College) ;
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Park, Hyun
(Wonkwang University Medical College) ;
- Kim, Sook-Hyang (Wonkwang University Medical College) ;
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Kim, Jae-Jin
(Department of Biology, Pai Chai University) ;
-
Min, Duk-Young
(Hanyang University Medical College)
- 발행 : 1993.12.01
초록
Contamination of heavy metals in water and sediments along Mantyeong (river) has reached up to critical level, The object of the study is to dlucidate some macroinvertebrates which inhabit along the river in respect to the modulatory role in reducing the pollution. For the purpose, Scapharca subcrenata(sea shell) which is common in numbers and biomass in the area was collected, and cadmium (Cd) was subjected as a reference metal in the experiment. The seashell was dried and autoclaved, followed by pellet preparation under various concentration of Cd: 50,100,250,500 and 1,500 ug /pellet. Mice were fed for 3 months, althrough last group(5 mice), 1,500 ug/pellet, died within 4 weeksof the administration.MT-Cd in liver and kidney increased in correlation with the amont of Cd concentration in pellet, especially in kidney than in liver. Liver and kidney of the mice showed pathological changes such as cellular infiltration and focal necrosis in liver, and peri-tubular cell infiltration or tubular necrosis etc. The changes were more intensive by amount of the Cd. Overall results in the present study suggest that Cd may eventually combine with soluble-protein forming metalloprotein, then reduce the toxicity of heavy metal, How the formed Mt-Cd is discharged from the kidney and the mechanism shall be the further subject to be clarified.
키워드