CHANGES IN SUBPOPULATION OF BRONCHOALVEOLAR LAVAGE FLUID IN THE PULMONARY FIBROSIS INDUCED BY BLEOMYCIN OR PEPLOMYCIN

  • Kim, Dae-Joong (Department of Pathlogy National Institute of Safety Research)
  • 발행 : 1993.12.01

초록

Present studies were carried out in order to estabilish the bronchoalveolar lavage method and to examine the response of bleomycin and peplomycin on the total cell number and the subpoulations of bronchoalveolar lavage fluid. A total of 24 male F344 rats, weighing 300-350 mg, were divided into 3 groups. Animals recelved either belomycin (BLM` 0.75 mg/0.2 ml/rat), peplomycin (PLM` 0.25mg/0.2ml/rat) for groups 2 and 3 or an equal volume of sterile saline lacking drugs for controls (group 1).

키워드

참고문헌

  1. The Report of Nat'l. Inst. Safety res. v.1 A pathological study on the peplomycin-induced pulmonary fibrosis in rats Bae,J.H.;Kim,D.J.;Yoon,C.H.;Kim,K.K.
  2. J. Clin. Invest v.72 Mechanisms of pulmonary fibrosis. Spontaneous release of the alvelor macrophage-derived growth factor in the interstitial lung disorders Bitterman,P.B.;Adelberg,S.;Crystal,R.G.
  3. Am. Rev, Respir. Dis. v.122 Pulmoary endothelial dysfunction in the presence or absence of interstitial injury induced y intratracheally injected bleomycin in rabbit Catravas,J.D.;Lazo,J.S.;Dobuler,K.J.;Mills,L.R.;Gillis,C.N.
  4. J. Immoun. v.139 Prostaglandin syntehsis and release by subpopulations of rat alveolar machrophage Chandler,D.B.;Fulmer,J.D.
  5. J. Leukoc. Biol. v.9 Fractionation of rat alveolar macrophses by isopycnic centrifugation: Morphological, cytochemical, biochemical and functional properties Chandler,D.B.;Fuller,W.C.;Jackson,R.M.;Fulmer,J.D.
  6. Am. Rev. Respri. Dis. v.133 Studies of memberance receptors and phagocytosis in subpopulations of rat alveolar macrophages Chandler,D.B.;Fuller,W.C.;Jackson,R.M.;Fulmer,J.D.
  7. Am. Rev. Respir. Dis. v.135 Modulation of the effects of alveolar macrophages on lung fibroblast collagen production rate Clark,J.G.;Greenberg,J.
  8. J. Clin. Invest v.72 Bleomycin-induced pulmonary fibrosis in hamsters:An alveolar macrophage product that increases fibroblast prostaglandin E2 and cyclic adenosine monophosphate and suppresses fibroblast proliferaton and collagen production Clark,J.G.;Kostel,K.M.;Marion,B.A.
  9. N. Engl. J. Med. v.310 Interstitial lung disease of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract(first of 2 parts) Crystal,R.G.;Bitterman,P.B.;Rennard,S.I.;Hance,A.J.;Koegh,B.A.
  10. Ann. Intern. Med. v.92 Immunological abnormalities in sarcoidosis Daniele,R.P.;Dauber,J.H.;Rossman,M.D.
  11. Am. Rev. Respir Dis. v.131 Human alveolar macrophage inhibition of lung fibroblast growth. A prostaglandin-dependent process Elias,J.A.;Rossman,M.D.;Zurier,R.B.;Daniele,R.P.
  12. Am. J. Pathol. v.140 Changes in distribution, morphology, and tumor necrosis factor -α secretion of alveolar macrophage subpopulations during the development of bleomycin-induced pulmonary fibrosis Everson,M.P.;Chandler,D.B.
  13. Arch. Environ. Health. v.36 The effect of paraquat and superoxide dismutase on pulmonary vascular permeability and edema in mice Giri,S.N.;Hollinger,M.A.;Schiedt,M.J.
  14. Toxicol. Pathol. v.14 Analysis of bronchoalveolar lavage fluid from bleomycin-induced pulmonary fibrosis in hamsters Giri,S.N.;Hyde,D.M.;Nakashima,J.M.
  15. N. Engl. J. Med. v.310 The pulmonary alveolar macrophage Hocking,W.G.;Golde,D.W.
  16. N. Engl. J. Med. v.310 The pulmonary alveolar macrophage Hocking,W.G.;Golde,D.W.
  17. J. Clin. Invest. v.66 Human alveolar macrophage-derived chemotactic factor for neutrophils Hunninghake,G.W.;Gadek,J.E.;Fales,H.M.;Crystal,R.G.
  18. Am. Rev. Respir. Dis. v.123 Characterization of the inflammatory and immune effector cells in the lung parenchyma of patients with interstitial lung disease Hunninghake,G.W.;Kawanimi,O.;Ferrans,V.J.;Young,R.C.;Roberts,W.C.;Crystal,R.G.
  19. Am. Rev. Respir. Dis v.128 The role of macrophage-derived chemoattractant activities in the early inflammatory events of bleomycin-induced pulmonary injury Kaelin,R.M.;Center,D.M.;Bernardo,J.;Grant,M.;Snider,G.L.
  20. Korean J. Lab. Anim. Sci. v.4 A study on the pulmonary fibrosis in rats after a single nonsurgical intratracheal dose of bleomycin Kim,D.J.;Lee,J.S.
  21. Seoul Univ. J. Vet. Sci. v.17 no.2 Pathological study of effects of verapamil on the pulmonary lesions induced by bleomycin in rats Kim,D.J.;Lee.J.S.
  22. J. Leukoc. Biol. v.37 Secretion of macrophage-derived growth factor during acute injury induced by bleomycin Kovacs,E.L.;Kelley,J.
  23. Am. Rev. Respir. Dis. v.177 Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin:Pathology and sterology Snider,G.L.;Hayes,J.A.;Kortly,A.L.
  24. Am. Rev. Respir. Dis. v.117 Chronic interstitial pulmonary fibrosis produced in hamster by endotracheal injection of bleomycin. Lung bolumes. Voluem-pressure relations, carbon monoxide uptake, and arterial bolld gas studied Snider,G.L.;Celli,B.R.;Goldstein,R.H.;O'Brien,J.J.;Lucey,E.C.
  25. Am. Rev. Respir. Dis. v.126 Differential cellualr analysis of bronchoalveolar lavage fluid obtained at various stages during the development of bleomycin-induced pulmonary fibrosis in the rat Thrall,R.S.;Barton,R.W.;D'Amato,D.D.;Sulavik,S.B.
  26. Ann. Intern. Med. v.89 Bronchoalveolar lavage in interstitial lung disease Weinberger,S.E.;Kelman,J.A.;Elson,N.A.;Young.R.C.;Reynolds,H.Y.;Fulmer,J.D.;Crystal,R.G.