Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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배양된 해마 신경세포의 성장에 대한 납의 영향

  • 김율아 (한림대학교 의과대학 약리학교실) ;
  • 김종곤 (한림대학교 의과대학 약리학교실) ;
  • 김용식 (서울대학교 의학대학 약리학교실) ;
  • 김영희 (한림대학교 의과대학 약리학교실) ;
  • 송동근 (한림대학교 의과대학 약리학교실)
  • Published : 1993.12.01
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Abstract

Lead is an environmental toxicant that causes a marked deficit in cognative development in infants and children. Damage to the hippocampus has been linked to the lead-induced deficit in the learning process. The present study examined the effects of lead on the development of hippocampal neurons in vitro. Hippocampal neurons were incubated with various concentrations in lead acetate (1nM to 30 nM) for 72 hrs from 4 h after plating, and the percentage of living neurons bearing neurites, neurite outgrowth and migration of multipolar neurons in culture were determined.

Keywords

References

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