YAKHAK HOEJI (약학회지)
- Volume 37 Issue 5
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- Pages.544-548
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- 1993
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Pharmacokinetics of DWP302, a New Combined Ranitidine Preparations for Gastroduodenal Diseases
라니티딘을 함유한 새로운 위장질환 치료용 의약조성물(DWP302)의 약물동태
Abstract
The pharmacokinetics of DWP302, a new combined ranitidine preparation in rats and dogs was studied using HPLC. DWP302 was composed of ranitidine, sucralfate and tripotassium dicitrato bismuthate. Especially, this study was focused on the possibilities that the concomitant administration of either sucralfate or TDB may affect the absorption of orally administered ranitidine. Ranitidine and DWP302 were orally administered to rats at a dose of ranitidine 10mg/kg. Several rats showed the biphasic peak of plasma concentration. AUC
Keywords
- Ranitidine;
- DWP302;
- tripotassium dicitrato bismuthate(TDB);
- sucralfate;
- pharmacokinetics;
- rat;
- dog;
- absorption;
- plasma