YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anti-thrombotic Effects of Analogs of Protocatechuic Acid and Gallic Acid

Protocatechuic acid 및 Gallic acid 유도체들의 항 혈전작용

  • 윤혜숙 (서울대학교 천연물과학연구소) ;
  • 강삼식 (서울대학교 천연물과학연구소) ;
  • 김문희 (서울대학교 천연물과학연구소) ;
  • 정기화 (덕성여자대학교 약학대학)
  • Published : 1993.10.01
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Abstract

Platelet anti-aggregating activities were tested with analogs of protocatechuic acid and gallic acid. Six of them which showed comparable inhibitory effects with aspirin against collagen induced platelet aggregation were selected and their anti-thrombotic effects were evaluated in the mouse thrombosis model and compared with those of aspirin and paeonol. At the dose of 50 mg/kg, p.o., ethyl gailate(13) treated group showed higher % of recovery within 6 min of thrombotic challenge and lower mortality within 5 min than aspirin treated group.

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