YAKHAK HOEJI (약학회지)
- Volume 37 Issue 3
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- Pages.262-269
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- 1993
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Metabolism of Poncirin by Intestinal Bacteria
장내 세균에 의한 폰시린의 대사
Abstract
Poncirin which is one of the flavanone rhamnoglucosides showed anti-inflammatory activity as the major component of fruit of Poncirus trifoliata. Poncirin did not show antiinflammatory effect when it was intraperitoneally administered, but it was very effective when orally administered. Poncirin was not metabolized by blood and liver enzymes but by intestinal bacteria of human and rats. Among the human intestinal bacteria, Streptococcus Y-25 converted poncirin to ponciretin through the poncirenin and Staphylococcus Y-88 converted to ponciretin directly.