YAKHAK HOEJI (약학회지)
- Volume 37 Issue 3
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- Pages.243-246
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- 1993
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of N-Substituted 5-Hydroxyanthranilic Acid
N-치환 5-Hydroxyanthranilic acid의 합성
Abstract
Six N-substituted-5-hydroxyanthranilic acids were synthesized by the coupling reaction of 5-tosyloxyanthranilic acid ethyl ester with corresponding acid chlorides. The structure of the obtained compounds was proved by NMR and IR. These compounds did not inhibit the growth of micro-organisms while suppressed HSV-1 replication in vero cell at 100