Ring Transformation Reaction of Thiazolo[3,2-$\alpha$][1,3]diazepinium-Betaine

티아졸로[3,2-$\alpha$[1,3]디아제핀-베타인의 고리변환 반응

  • 박미선 (이화여자대학교 약학대학) ;
  • 서명은 (이화여자대학교 약학대학) ;
  • 유경호 (한국과학기술연구원) ;
  • 박상우 (이화여자대학교 약학대학)
  • Published : 1993.04.01

Abstract

3-Phenyl-5, 6, 7, 8-tetrahydrothiazolo[3, 2-$\alpha$][1, 3]diazepine, which has pharmaceutical activities, was reacted with phenyl isothiocyanate to give 3-phenyl-9-phenyl(thiocarbamoyl)-5, 6, 7, 8-tetrahydrothiazolo[3, 2-$\alpha$][1, 3]diazepi nium-betaine. New biheterocyclic compounds were prepared by the ring transformation reaction of the above reactive betaine with $\alpha$-haloesters and $\alpha$-haloketones such as ethyl bromoacetate, methyl bromoacetate, chloroacetone, and 4'-methoxyphenacyl bromide, respectively. In each ring transformation reaction, two major products supposed to be geometrical isomers were obtained.

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