Archives of Pharmacal Research
- Volume 16 Issue 3
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- Pages.237-243
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- 1993
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effects of Ginseng Total Saponins on the Antinociception and the Tolerance Development of U-50,488H
- Kim, Hack-Seang (Department fo Pharmacology, College of Pharmacy,Chungbuk National University) ;
- Kim, Sun-Hye (Department fo Pharmacology, College of Pharmacy,Chungbuk National University) ;
- Seong, Teon-Hee (Department of Veterinary Pharmacology, College of Agriculture, Chungbuk National University) ;
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Oh, Ki-Wan
(Department fo Pharmacology, College of Pharmacy,Chungbuk National University)
- Published : 1993.09.01
Abstract
These studies were performed to investigate the acting sites of ginseng total saponins (GTS) on the U-50, 488H-induced antinociception and the inhibitory effect of the development of tolerance to U-50, 488H-induced antinociception by GTS were studied. The U-50, 488H-induced antinociception was ntagonized in mice pretreated with GTS intraperitoneally, intracerebrally. These antagonisms were reversed by the pretratment iwth a serotonin precursor, 5-hydroxytrypophan (5-HTP), but not with a noradrenaline precursor, L-dihydroxyphenylalanine (L-DOPA). However, the intraplantar sites. On the other hand, GTS inhibited the development of tolerance to U-50, 488H-induced antinociception was reversed by pretreatment with 5-HTP, but not with L-DOPA. Therefore, the antagonism of U-50, 488H-induced antinociception and the inhibition of the development of tolerance to U-50, 488H-induced antinociception and the inhibition of the development of tolerance to U-50, 488H-induced antinociception by GTS are dependent on serotonegic mechanisms.
Keywords
- U-50;
- 488H-induced antinociception;
- Antagonism;
- Tolerance;
- Ginseng total saponins(GTS);
- Serotonergic mechanisms