Archives of Pharmacal Research
- 제16권3호
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- Pages.209-212
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- 1993
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Anticoagulant Activity of Ilexoside D, a Triterpenoid Saponin from ilex pubescens
- Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
- Song, Jae-Ihn (Natural Products Research Institute, Seoul National University) ;
- Rhee, In-Kyung (Natural Products Research Institute, Seoul National University)
- 발행 : 1993.09.01
초록
The anti-coagulant activity of ilexoside D isolated from the roots of ilex pubescens Hook. et Am. was investigated in in vivo models of blood coagulation in rats. On oral administration, ilexoside D prolonged the bleeding time and the whole blood recalcified clotting time, but not the plasma recalcified clotting time. In vitor, ilexoside D did not affect the recalciffed clotting times of whole blood, platelet-rich plasma(PRP), and platelet-poor plasma(PPP), while in the presence of tissue factor the compound prologed the reduced proth-rombin times of whole blood, PRP and PPP in the dose-dependent manner. These results indicate that ilexoside D has the anit-tissue factor activity as well as the antithromobotic activity.