Effects of n-Alkanols on the Rotational Relaxiation Time of 1,6-Diphenyl-1,3,5-hextriene in the Synaptosomal Plasma Membrane Vesicles Isolated from Bovine Cerebral Cortex

The effects of n-alkanols on the rotational relaxation time of 1, 6-dipheny-1, 3, 5-hexatriene (DPH) in synaptosomal plasma membrane vesicles isolate from fresh bovine cerbral contex were investigated. n-Alknols decreased the rotational relaxation time of 1, 6-diphenyl-1, 3, 5-hexatriene in the native membranes and the potencies of n-alkanols up to 1-nonanol increased by 1 order of magnitude as the carbon chain length increases by two carbon atoms, The cut-off phenomenon was reached at 1-decanol, where further increase in hydocabon length resulted in an increase in the rotational relaxation time of DPH in the native membranes.