Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 3 Issue 2
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- Pages.163-168
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- 1993
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Effect of Cimetidine on the Hepatic Blood flow -On the Basis of Pharmacokinetics of Indocvanine Green in Rats-
시메티딘이 간혈류량에 미치는 영향 - Rat에 있어서 Indocyanine Green의 체내 동태를 중심으로 -
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Lee, Yong-Bok
(College of Pharmacy, Chonnam National University) ;
- Koh, Ik-Bae (College of Pharmacy, Chonnam National University)
- Published : 1993.12.01
Abstract
The influence of cimetidine pretreatment(100mg/kg, single i.p.) on the hepatic blood flow was investigated using pharmacokinetic parameters of indocyanine green(ICG) in the rat on the basis of hepacc perfusion-limited model. ICG(1mg/kg) was respectively administered via femoral and portal vein to the control and to the cimetidine-pretreated rats. The rate constant K12, K20 and the systemic clearance(CLt) of ICG were significantly(p<0.05) decreased ill the cimetidine-pretrea-to(B rats, but no significant diffirences were observed in hematocrit and liver weight. The biliary excretion rates of ICG were also decreased regardless of the route of administration in the cimetidine-pretreated rats. And also the hepatic blood flow in rats was decreased about
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