Radiation Therapy Result of Polymorphic Reticulosis

다형성 세망증(Polymorphic Reticulosis)의 방사선 치료 성적

  • Chung, Eun-Ji (Department of Radiation Oncology, Yonsei University, College of Medicine, Yonsei Cancer Center) ;
  • Kim, Gwi-Eon (Department of Radiation Oncology, Yonsei University, College of Medicine, Yonsei Cancer Center) ;
  • Park, Young-Nyun (Department of Pathology, Yonsei University, College of Medicine, Yonsei Cancer Center)
  • 정은지 (연세대학교 의과대학 치료방사선과, 연세암센터) ;
  • 김귀언 (연세대학교 의과대학 치료방사선과, 연세암센터) ;
  • 박영년 (연세대학교 의과대학 병리학교실, 연세암센터)
  • Published : 1993.06.01

Abstract

During the period from January, 1975, to June, 1989, one hundred patients with histopathologically proven polymorphic reticulosis in the upper respiratory tract were treated with radiation therapy and the analysis of treatmemt results was undertaken. One hundred patients (69 males, 31 females) with a mean age of 46 years (range 12-79 years) were presented. Nasal cavity was the most frequent site of involvement ($56{\%}$), and 44 cases had multifocal sites of involvement. The incidence of cervical lymph node metastasis at initial diagnosis was $24{\%}$. Staging was determined by Ann-Arbor classification, retrospectively. The number of patients of stage IE, IIE, IIIE and IVE were 35, 60, 1, and 4, respectively. The overall 5 year actuarial survival rates were $38.4{\%}$. The difference in 5 year survival rates between patients with stage IE and IIE, with solitary and multiple, with CR and PR after irradiation were significant statistically. For the analysis of failure patterns, failure sites include the following: local failure alone (30/55=$54.6{\%}$), systemic failure alone (9/55=$16.4{\%}$), both local and systemic failure (16/55=$29.0{\%}$). Retrograde slide review was available in 29 cases of PMR with respect to histopathologic bases, and immunohistochemical studies were performed using MT1 and DACO-UCHL-1 as T-cell markers, MB2 as a B-cell marker and alpha-1-antichymotrypsin as a histiocytic markers. All that 29 cases showed characteristic histologic features similar to those of peripheral T-cell lymphoma and showed positive reactio to the T-cell marker. These findings suggest strongly that quite a significant portion of PMR may be in fact T-cell lymphoma.

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