Radiation Oncology Journal
- Volume 11 Issue 1
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- Pages.17-27
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- 1993
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
Relationship between Radiosensitivity and Repair Capacity in Human Epithelial Cancer Cell Lines
인체 상피암 세포주에서 방사선감수성과 손상회복의 상관관계에 관한 연구
- Koh, Kyoung-Hwan (Department of Therapeutic Radiology, College of Medicine, Seoul National University) ;
- Ha, Sung-Whan (Cancer Research Center, Seoul National University) ;
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Park, Charn-Il
(Department of Therapeutic Radiology, College of Medicine, Seoul National University)
- Published : 1993.06.01
Abstract
To investigate the relationship between radiosensitivity and postirradiation recovery in human cancer cells, a study was performed using human cancer cell lines-A549, CaSki, SNU-C5 and PCI-13. For the study of radiosensitivity, single doses of 2, 4, 6, 8, 10, 12, and 14 Gy were given and for postirradiation recovery, two fractions of 4 Gy were separated with a time interval of 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, or 6 hours. Surviving fraction was estimated using colony forming ability. Surviving fractions at 2 Gy (SF2) were 0.496 (0.570-0.412) for A549, 0.496 (0.660-0.332) for CaSki, 0.386 (0.576-0.216) for SNU-C5, and 0.185 (0.247-0.123) for PCI-13. By statistical analysis the SF2 of PCI-13 was lower significantly than those of others (p<0.05). This difference was also observed at 4, 6 and 8 Gy dose levels. At 6 and 8 Gy the surviving fractions of SNU-C5 were also lower significantly than A549 and CaSki (p<0.05). By the analysis with linear quadratic model, the values of
Keywords
- Radiosensitivity;
- Irradiation;
- Human cancer cell lines;
- Postirradiation recovery ratio;
- A549;
- CaSki;
- SNU-C5;
- PCI-13