Journal of Pharmaceutical Investigation
- 제23권4호
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- Pages.217-223
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- 1993
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
제산제와 항궤양제 복합제제의 In Vitro 및 In Vivo 제산력 평가
In Vitro and In Vivo Evaluation of the Combined Products of Antacid and Anti-ulcer Drug
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Kim, Chong-Kook
(College of Pharmacy, Seoul National University) ;
- Ahn, Hye-Jin (College of Pharmacy, Seoul National University) ;
- Jeong, Eun-Joo (College of Pharmacy, Seoul National University) ;
- Oh, Kyung-Hee (College of Pharmacy, Seoul National University) ;
- Lah, Woon-Lyong (College of Pharmacy, Seoul National University)
- 발행 : 1993.12.20
초록
The combined products of antacid and anti-ulcer agent were prepared with antacid composed of aluminium hydroxide dried gel, magnesium hydroxide and simethicone with a ratio of 1:1:0.1 (M) and anti-ulcer agent, aceglutamide aluminium (AGA). The efficacy of antacid was evaluated in vitro with Fuchs, Johnson-Duncan and Rosset-Rice methods and in vivo using an aspiration method in rat. The addition of anti-ulcer agent did not affect the neutralizing capacity of M significantly. The combined products with the M/AGA ratios of 2.3:1 and 3.4:1 produced the maximum pH of
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