Journal of Pharmaceutical Investigation
- Volume 23 Issue 2
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- Pages.103-110
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- 1993
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Biopharmaceutical Evaluation of Sustained-Release $Eudragit^{\circledR}$ Microcapsules Containing Cephalexin
서방성 $Cephalexin-Eudragit^{\circledR}$ 마이크로캅셀의 생물약제학적 평가
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Han, Kun
(College of Pharmacy, Chungbuk National University) ;
- Kim, Kwang-Dug (College of Pharmacy, Chungbuk National University) ;
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Chung, Youn-Bok
(College of Pharmacy, Chungbuk National University) ;
- Jee, Ung-Kil (College of Pharmacy, Chungnam National University) ;
- Kim, Shin-Keun (College of Pharmacy, Seoul National University)
- Published : 1993.06.20
Abstract
Microcapsules(Mc) of cephalexin (CEPH), using Eudragit RS, RL, L, S and polyethylene glycol 1540, were evaluated biopharmaceutically. The area under the curve of CEPH-Eudragit RS/RL Mc administered orally once was larger than that of cephalexin powder twice every 6 hrs. Controlledrelease effectiveness and the absorption rate effectiveness, two important parameters of Vallner's method, of CEPH-Eudragit RS/RL Mc indicate that these Mc can be good sustained-release preparations. And a simple pharmacokinetic model is introduced which allows the gastric emptying and intestinal-transit rates of a drug itself and a solid-state drug contained in Mc. Decreasing
Keywords
- Cephalexin;
- Eudragit RS/RL;
- Sustained release microcapsules;
- AUC;
- Vallner's method;
- Pharmacokinetic model