Journal of Pharmaceutical Investigation
- 제23권1호
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- Pages.51-53
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- 1993
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
점막 부착정제의 물성평가(I):-부착력-
Evaluation of Physical Properties of Mucosal Adhesive Tablets (I):-Adhesive Force-
- Park, Kwang-Sin (Research Laboratories, Dong-A Pharm. Co.) ;
- Chung, Bee-Hwan (Research Laboratories, Dong-A Pharm. Co.) ;
- Cha, Bong-Jin (Research Laboratories, Dong-A Pharm. Co.) ;
- Kwon, Jong-Won (Research Laboratories, Dong-A Pharm. Co.)
- 발행 : 1993.03.20
초록
Mucoadhesive tablets containing hydroxypropylcellulose-H (HPC) and carbopol 934 (CP) were prepared from direct compression. Their adhesive forces and water absorptions were investigated by using mouse peritoneal membrane and 1.5% agar plate, respectively. Adhesive force was significantly improved with increasing CP concentration, but was not affected by compression force and addition of disintegrants. And adhesive force to mouse peritioneal membrane was increased as fixing time increased. In conclusion, adequate adhesive force can be obtained by control of CP/HPC ratio and fixing time.