생약학회지 (Korean Journal of Pharmacognosy)

  • 제24권3호
  • /
  • Pages.223-230
  • /
  • 1993
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

전통 약용식물의 항암효과에 대한 연구

Antineoplastic Effect of Extracts from Traditional Medicinal Plants

  • 박재갑 (서울대학교 의과대학 암연구소 및 암연구센타 세포생물학 연구부) ;
  • 현진원 (서울대학교 의과대학 암연구소 및 암연구센타 세포생물학 연구부) ;
  • 임경화 (서울대학교 의과대학 암연구소 및 암연구센타 세포생물학 연구부) ;
  • 신진이 (서울대학교 의과대학 암연구소 및 암연구센타 세포생물학 연구부) ;
  • 원용진 (서울대학교 천연물과학연구소) ;
  • 이영득 (서울대학교 천연물과학연구소) ;
  • 신국현 (서울대학교 천연물과학연구소) ;
  • 장일무 (서울대학교 천연물과학연구소) ;
  • 우원식 (서울대학교 천연물과학연구소)
  • Park, Jae-Gahb (Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
  • Hyun, Jin-Won (Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
  • Lim, Kyoung-Hwa (Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
  • Shin, Jin-E (Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
  • Won, Yong-Jin (Natural Products Research Institute, Seoul National University) ;
  • Yi, Young-Deuk (Natural Products Research Institute, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Chang, Il-Moo (Natural Products Research Institute, Seoul National University) ;
  • Woo, Won-Sick (Natural Products Research Institute, Seoul National University)
  • 발행 : 1993.09.30
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초록

Antineoplastic activity against human gastric, colon and hepatocellular carcinoma cell lines were measured in 100 extracts from 80 medicinal plants using MTT (3-[4, 5-dimethyl thiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) method. Seventeen extracts from fourteen plants, all of which have previously been reported to have antineoplastic effect, had $IC_{50}$(50% inhibitory concentration) values of less than $230{\;}{\mu}g/ml$ in at least one of the three cell lines. Extracts from remaining sixty-six medicinal plants failed to show significant cytotoxic effect at the concentration of less than $230{\;}{\mu}g/ml$.

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