The Korean Journal of Physiology
- Volume 27 Issue 2
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- Pages.115-122
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- 1993
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- 0300-4015(pISSN)
Effects of Noradrenaline on the Spontaneous Contraction and Ionic Current in the Antral Circular Muscle of Guinea-pig Stomach
- Jun, Jae-Yeoul (Department of Physiology & Biophysics Seoul National University College of Medicine) ;
- Lee, Sang-Jin (Department of Physiology & Biophysics Seoul National University College of Medicine) ;
- Kim, Sung-Joon (Department of Physiology & Biophysics Seoul National University College of Medicine) ;
- Suh, Jae-Yul (Department of Physiology & Biophysics, Seoul National University College of Medicine) ;
- So, In-Suk (Department of Physiology & Biophysics Seoul National University College of Medicine) ;
- Hwang, Sang-Ik (Department of Physiology & Biophysics Seoul National University College of Medicine) ;
- Kim, Ki-Whan (Department of Physiology & Biophysics Seoul National University College of Medicine)
- Published : 1993.12.01
Abstract
There is evidence that noradrenaline enhances spontaneous contractions dose-dependently in guinea-pig antral circular muscle. To investigate the mechanism of this excitatory action, slow waves and membrane currents were recorded using conventional microelectrode techniques in muscle strips and the whole cell patch clamp technique in isolated gastric myocytes. On recording slow waves, noradrenaline
Keywords
- Noradrenaline;
- Slow waves;
- Voltage-dependent $Ca^{2+}\;
- currents;
- \;
- Ca^{2+}-dependent\;
- K^+\;
- currents$Apamin