The Korean Journal of Physiology
- 제27권1호
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- Pages.67-77
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- 1993
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- 0300-4015(pISSN)
Acute and Chronic Effects of Ethanol on the Cardiovascular and Hormonal Responses to Hemorrhage in Conscious Normotensive and Spontaneously Hypertensive Rats
- Park, Yoon-Yub (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Lee, Joong-Hee (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Park, Jae-Sik (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Yang, Eun-Kyoung (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Ahn, Dong-Kuk (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Kim, Hyeong-Jin (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Lee, Won-Jung (Department of Physiology, School of Medicine, Kyungpook National University)
- 발행 : 1993.06.01
초록
Acute and chronic effects of ethanol (EOH) administration on the cardiovascular and hormonal responses to repeated hemorrhage were investigated in conscious normotensive Wistar rats and spontaneously hypertensive rats (SHR). The chronic EOH treated group received 5% EOH (vol/vol) ad libitum in the drinking water far the first week,10% for the last 2 weeks, and 20% for the last 5 weeks from the age of 6 weeks. The EOH free group received tap water. Chronic EOH and EOH free groups were randomly subdivided into acute EOH infusion and control groups. Under ether anesthesia, catheters were inserted into the femoral vein and both femoral arteries. After rats regained consciousness and their blood pressure was stabilized, responses to quick hemorrhage (5 ml/kg BW) were tested. In the acute EOH infusion group, hemorrhage was induced 20 min after EOH infusion (1.0 g/kg BW), Baroreceptor reflex sensitivity was assessed by the ratio of changes in hen.1 rate and mean arterial pressure (