The Korean Journal of Physiology
- Volume 27 Issue 1
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- Pages.57-66
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- 1993
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- 0300-4015(pISSN)
Effect of Nifedipine on Endocrine and Cardiovascular Responses to Angiotensin II in SHR Fed with Different Sodium Diets
- Choi, Eun-Kyung (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Park, Yoon-Yub (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Ahn, Dong-Kuk (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Park, Jae-Sik (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Lee, Won-Jung (Department of Physiology, School of Medicine, Kyungpook National University)
- Published : 1993.06.01
Abstract
Effects of a voltage dependent calcium channel antagonist, nifedipine, on the responses of blood pressure, and secretion of atrial natriuretic peptide (ANP) and aldosterone to angiotensin II (Ang II) were compared in male Wistar and spontaneously hypertensive rats (SHR). A low, control or high sodium diet (2, 10 or 25 mmol Na/100 g diet) was fed for 6 weeks from the age of 6 weeks. On the morning of the experiment catheters were inserted under ether anesthesia in the femoral artery for pressure recording and blood sampling, and in the femoral vein for drug infusion. Ang II was infused at a rate of 250 ng/kg/min for 20 min. Nifedipine mixed with Ang II was infused at a rate of