Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)

Korean Society for Clinical Pharmacology and Therapeutics (대한임상약리학회)
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Treatment of 2 Cases of Atopic Dermatitis using Cyclosporine and Ketoconazole Drug Interaction

Cyclosporine과 Ketoconazole의 약물상호작용을 이용한 아토피 피부염 치험 2예

  • Kim, Dong-Won (Department of Dermatology, Soeul National University Colleges of Medicine) ;
  • Pyo, Hyung-Chan (Department of Dermatology, Soeul National University Colleges of Medicine) ;
  • Lee, Yoo-Shin (Department of Dermatology, Soeul National University Colleges of Medicine) ;
  • Eun, Hee-Chul (Department of Dermatology, Soeul National University Colleges of Medicine)
  • 김동원 (서울대학교 의과대학 피부과학교실) ;
  • 표형찬 (서울대학교 의과대학 피부과학교실) ;
  • 이유신 (서울대학교 의과대학 피부과학교실) ;
  • 은희철 (서울대학교 의과대학 피부과학교실)
  • Published : 1993.05.31

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Abstract

Cyclosporine has been mainly used for the prevention of rejection after kidney transplantation. Recently, it has been also tried for the treatment of skin diseases including atopic dermatitis. There have been several reports that ketoconazole can increase blood cyclosporine level if both drugs are taken together and its mechanism is thought to be related to hepatic cytochrome P-450. As cyclosporine is still expensive drug and major organ of side effect of ketoconazole is liver not kidney as cyclosporine. we think combination treatment is justifable. We have successfully treated 2 cases of atopic dermatitis with combination treatment and effective blood levels of cyclosporine were observed without major side effect.

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