Clinical and Experimental Reproductive Medicine

  • 제19권1호
  • /
  • Pages.81-85
  • /
  • 1992
  • /
  • 2233-8233(pISSN)
  • /
  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
권호 표지

GnRH의 맥동성 투여에 의한 남성 성선기능저하증의 치료

Pulsatile GnRH Therapy in Male Patients with Hypogonadotropic Hyprogonadism

  • 박기현 (연세대학교 의과대학 산부인과학교실) ;
  • 지용석 (연세대학교 의과대학 산부인과학교실) ;
  • 이병석 (연세대학교 의과대학 산부인과학교실) ;
  • 이보연 (연세대학교 의과대학 산부인과학교실) ;
  • 조동제 (연세대학교 의과대학 산부인과학교실) ;
  • 송찬호 (연세대학교 의과대학 산부인과학교실) ;
  • 이무상 (연세대학교 의과대학 비뇨기과학교실) ;
  • 최형기 (연세대학교 의과대학 비뇨기과학교실) ;
  • 이현철 (연세대학교 의과대학 내과학교실) ;
  • 허갑범 (연세대학교 의과대학 내과학교실)
  • Park, Ki-Hyun (Department of Obstetrics and Gynecology, Yonsei University College of Medicine) ;
  • Jee, Yong-Seok (Department of Obstetrics and Gynecology, Yonsei University College of Medicine) ;
  • Lee, Byung-Seok (Department of Obstetrics and Gynecology, Yonsei University College of Medicine) ;
  • Lee, Bo-Yun (Department of Obstetrics and Gynecology, Yonsei University College of Medicine) ;
  • Cho, Dong-Jae (Department of Obstetrics and Gynecology, Yonsei University College of Medicine) ;
  • Song, Chan-Ho (Department of Obstetrics and Gynecology, Yonsei University College of Medicine) ;
  • Lee, Moo-Sang (Department of Urology, Yonsei University College of Medicine) ;
  • Choi, Hyung-Ki (Department of Urology, Yonsei University College of Medicine) ;
  • Lee, Hyun-Chul (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Heo, Kab-Beom (Department of Internal Medicine, Yonsei University College of Medicine)
  • 발행 : 1992.06.30
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초록

The effects of pulsatile GnRH therapy have been studied for the treatment of different forms of hypogonadotropic hypogonadism, including idiopathic hypogonadotropic hypogonadism and hypogonadism developed as a result of treatment with combination of surgery and irradiation for pituitary or hypothalamic tumor. GnRH was administered subcutaneously in a dose of $10{\mu}g$ every 2 hours with the pulsatile infusion pump. With GnRH therapy, all patients improved secretion of LH, FSH and testosterone. Testicular volumes increased. Spermatogenesis was induced in 8 patients. Pulsatile GnRH therapy is an effective treatment for idiopathic hypogonadotropic hypogonadism and can have a role in hypogonadism previously treated with combination of surgery and irradiation for pituitary or hypothalamic tumor.

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