Maxillofacial Plastic and Reconstructive Surgery
- Volume 14 Issue 3
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- Pages.245-253
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- 1992
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- 2288-8101(pISSN)
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- 2288-8586(eISSN)
EXPERIMENTAL STUDY ON TISSUE RESPONSE OF DEMINERALIZED XENOGENIC BONE MATRIX IN EXTRASKELETAL SITE
탈회된 인체 이종골 매식체의 조직 반응에 대한 실험적 연구
- Jin, Kuk-Byum (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Wonkwang University) ;
-
Kim, Soo-Nam
(Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Wonkwang University) ;
- Um, In-Woong (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Wonkwang University) ;
- Kim, Kue-He (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Wonkwang University)
- 진국범 (원광대학교 치과대학 구강악안면외과학 교실) ;
-
김수남
(원광대학교 치과대학 구강악안면외과학 교실) ;
- 엄인웅 (원광대학교 치과대학 구강악안면외과학 교실) ;
- 김귀희 (원광대학교 치과대학 구강악안면외과학 교실)
- Published : 1992.09.30
Abstract
To evaluate the tissue response of demineralized and undimineralized xenogeneic bone-martrix graft in extraskeletal site, we prepared human bone as a implant matrix, and outbred mouse as a recipient. Before clinical application of bank bone of human in Wonkwang university, we should confirm the allogeneic bone grafts us a biologically useful bone graft substitutes, obtanined from the patients receiving oral and maxillofacial surgery. The clinical evaluation and histologic studies showed that both (demineralized and undemineralized) xenogeneic bone matrix grafts were not rejected and that they seemed to stimulate new bone formation at the transplanation site. Undemineralized xenogeneic bone marb6 grafts showed minimal bone induction and gradual demineralization with slow resorption and showed that the differentiation of cells showing fibroblastic activity adjacent to the sop tissue were slowly and less frequently than demineralized bone. Characteristical differences between the demineralized and undemineralized matrix were the appearance of foreign body giant cells (multinucleated giant cells) and the evidence of sloe resorption in undemineralized bone matrix.
Keywords