Journal of Yeungnam Medical Science

영남대 의대 학술지 편집위원회 (Yeungnam University College of Medicine, Yeungnam University Institute Medical Science)
권호 표지

Cisplatin의 신독성에 관한 연구

A Study of Cisplatin Nephrotoxicity

  • 황영희 (영남대학교 의과대학 소아과학교실) ;
  • 이경아 (영남대학교 의과대학 소아과학교실) ;
  • 신손문 (영남대학교 의과대학 소아과학교실) ;
  • 박용훈 (영남대학교 의과대학 소아과학교실) ;
  • 하정옥 (영남대학교 의과대학 소아과학교실) ;
  • 김춘동 (순천향구미병원 소아과) ;
  • 이영환 (성베드로영천병원 소아과)
  • Hwang, Young-Hee (Department of pediatrics College of Medicine, Yeungnam University) ;
  • Lee, Kyoung-A (Department of pediatrics College of Medicine, Yeungnam University) ;
  • Shin, Son-Moon (Department of pediatrics College of Medicine, Yeungnam University) ;
  • Park, Young-Hoon (Department of pediatrics College of Medicine, Yeungnam University) ;
  • Hah, Jeong-Ok (Department of pediatrics College of Medicine, Yeungnam University) ;
  • Kim, Chun-Dong (Department of Pediatrics Soonchunhyang Gumi Hospital) ;
  • Lee, Young-Hwan (Department of Pediatrics St. Peter's Yeongchun Hospital)
  • 발행 : 1992.12.30
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초록

To evaluate the nephrotoxicity of cisplatin, serum levels of sodium, potassium, chloride, calcium, phosphorous, magnesium, BUN, creatinine and creatinine clearance were measured before and after administration of cisplatin in 18 cases of patients with malignant neoplasm. The results were as follows : 1) Serum calcium, magnesium, potassium and BUN levels were changed after cisplatin administration, but those changes were not statistically significant. 2) The mean value of creatinine clearance was not decreased significantly after treatment with cisplatin. 3) Acute renal failure was developed in one case, and four cases of hypocalcemia, hypomagnesemia were also detected after administration of cisplatin.

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