Toxicological Research
- Volume 8 Issue 2
- /
- Pages.205-216
- /
- 1992
- /
- 1976-8257(pISSN)
- /
- 2234-2753(eISSN)
Acute toxicity of cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II)(SKI 2053R) in rats and Mice
랫드와 마우스에서 cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II)(SKI 2053R)의 급성독성에 관한 연구
- Kang, Kyung-Sun (College of Veterinary Medicine, Seoul National University) ;
- Shin, Dong-Jin (College of Veterinary Medicine, Seoul National University) ;
- Cho, Jae-Jin (College of Veterinary Medicine, Seoul National University) ;
- Kim, Hyoung-Ook (College of Veterinary Medicine, Seoul National University) ;
- Kim, Bae-Hwan (College of Veterinary Medicine, Seoul National University) ;
- Lee, Yong-Soon (College of Veterinary Medicine, Seoul National University)
- 강경선 (서울대학교 수의과대학 공중보건학교실) ;
- 신동진 (서울대학교 수의과대학 공중보건학교실) ;
- 조재진 (서울대학교 수의과대학 공중보건학교실) ;
- 김형욱 (서울대학교 수의과대학 공중보건학교실) ;
- 김배환 (서울대학교 수의과대학 공중보건학교실) ;
- 이영순 (서울대학교 수의과대학 공중보건학교실)
- Published : 1992.12.01
Abstract
cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II)(SKI 2053R), an antitumor platinum complex, was selected for clinical evaluation on the basis of its experimental antitumor and toxicologic profiles in preclinical studies. These studies were performed to obtain information on its toxic signs, orgnas which are mainly affected, and to estimate its lethality in mice and rats given SKI 2053R through two routes of administration. In male and female rats given a single intragastrical dose of SKI 2053R, we estimated that
Keywords
- cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum (II) (SKI 2053R);
- Acute toxicity;
- Rats;
- Mice