The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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$^{99m}Tc-HMPAO$ Brain SPECT in Medically Intraetable Epilepsy; Ictal Study

간질증후군의 $^{99m}Tc-HMPAO$ Brain SPECT; Ictal Study

  • Chung, Tae-Sub (Department of Radiology, Yonsei University College of Medicine) ;
  • Suh, Jung-Ho (Department of Radiology, Yonsei University College of Medicine) ;
  • Kim, Dong-Ik (Department of Radiology, Yonsei University College of Medicine) ;
  • Lee, Jong-Doo (Department of Radiology, Yonsei University College of Medicine) ;
  • Park, Chang-Yun (Department of Radiology, Yonsei University College of Medicine) ;
  • Hong, Yong-Kook (Department of Radiology, Yonsei University College of Medicine) ;
  • Lee, Byung-In (Department of Neurology, Yonsei University College of Medicine) ;
  • Huh, Kyun (Department of Neurology, Yonsei University College of Medicine)
  • 정태섭 (연세대학교 의과대학 진단방사선과학교실) ;
  • 서정호 (연세대학교 의과대학 진단방사선과학교실) ;
  • 김동익 (연세대학교 의과대학 진단방사선과학교실) ;
  • 이종두 (연세대학교 의과대학 진단방사선과학교실) ;
  • 박창윤 (연세대학교 의과대학 진단방사선과학교실) ;
  • 홍용국 (연세대학교 의과대학 진단방사선과학교실) ;
  • 이병인 (연세대학교 의과대학 신경과학교실) ;
  • 허균 (연세대학교 의과대학 신경과학교실)
  • Published : 1992.12.31
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Abstract

Both interictal and ictal $^{99m}Tc-HMPAO$ brain SPECT were performed in 22 patients with medically intractable epilepsy. Localization of epileptic foci in our patients was made by combined results of EEG and other tests, including Wada test, magnetic resonance imaging, and neuropsychometric test. Among them, ictal $^{99m}Tc-HMPAO$ SPECT, localized epilptic foci in 20 of 22 patients and provided evidence of epileptic focus in 12 patients by demonstrating maximally increased regional cerebral perfusion (rCP) in epileptic foci during the ictal study with decreased rCP in interictal study. Ictal $^{99m}Tc-HMPAO$ SPECT was particularly useful for investigating epileptic foci, and when correlated with simultaneously recorded ictal EEG, provided further insight for localizing epileptic foci. Conclusively, $^{99m}Tc-HMPAO$ SPECT is. a useful, noninvasive method of localizing epileptic activity which may be particularly important for presurgical investigations, especially in those patients without large morphological lesions.

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