Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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A Study on the Synthesis of New Medicinal Agents : Synthesis of 6-Thiocyanopenicillanic Acid Derivatives

새로운 의약품의 합성에 관한 연구 : 6-Thiocyanopenicillanic Acid 유도체의 합성

  • Lee Young-Haeng (Department of Chemistry, Won Kwang University) ;
  • Lee Chai-Ho (Department of Chemistry, Won Kwang University) ;
  • Choi Won-Sik (Department of Genetic Engineering, Soon Chun Hyang University)
  • Published : 1992.10.20
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Abstract

A new ${\beta}$-lactam compound, 6-thiocyanopenicillanic acid(1a) was prepared by the reaction of diazonium salt of 6-aminopenicillanic acid with sodium thiocyanate. Reaction of 6-thiocyanopenicillanic acid(1a) with p-nitrobenzyl bromide, chloromethylpivalate and 1-chlorodiethylcarbonate, respectively, afforded the corresponding esters(1b∼d)

6-aminopenicillanic acid의 diazo화 반응과 sodium thiocyanate와 반응으로 새로운 ${\beta}$-lactam 화합물인 6-thiocyanopenicillanic acid(1a)를 합성하고 p-nitrobenzyl bromide, chloromethylpivalate 및 1-chlorodiethylcarbonate들과의 반응에 의해 각각 해당되는 esters(1b∼d)를 합성하였다

Keywords

References

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