Journal of Nutrition and Health
- Volume 25 Issue 6
- /
- Pages.501-510
- /
- 1992
- /
- 2288-3886(pISSN)
- /
- 2288-3959(eISSN)
Effect of Dietary Coenzyme ${Q}_{10}$ on Lipid Peroxidation in Adriamycin-Treated Rats -III. Effect on Myocardial Ultrastructural Changes-
식이 중의 Coenzyme ${Q}_{10}$ 첨가가 Adriamycin을 투여한 흰쥐의 체내 지질과산화에 미치는 영향 -III. 심근 미세구조 변화에 미치는 영향-
Abstract
The present study was designed to evaluate the effect of pretreatment with coenzyme {{{{ { Q}_{10 } }}}} on adriamycin-induced myocardial ultrastructural changes in rats. Except control group 6 treat-ments included three levels of dietary conenzyme {{{{ { Q}_{10 } }}}} (0, 0.1 or 0.5g/kg diet) and two levels of ADR(1.0 or 2.0mg/kg B.W/week) Adriamycin treatment significantly decreased growth perfo-rmance of rats. But this decrement was not modified by dietary supplementation of coenzyme{{{{ { Q}_{10 } }}}} Electron microscopic examination revealed a progression of myocardial lesions were depen-dent upon the level of ADR injection. The most frequently observed fin structural alterations in rat myocardium were mitochondrial swelling dilation of the sarcoplasmic reticulum and the appearance of a perinuclear vacuolication. But these structural changes were somewhat reduced by dietary supplementation of coenzyme {{{{ { Q}_{10 } }}}}.
식이중에 첨가된 coenzyme