Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

EVALUATION FOR THE CONVULSIVE LIABILITY OF VARIOUS QUINOLONE DERIVATIVES IN MICE

  • Published : 1992.06.01
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Abstract

The present study was performed to evaluate whether the application of Fenbufen is reasonable for predicting the convulsive liability of the quinolone derivatives and to examine whether pentylenetetrazole (PTZ) can be used as a screening tool for their Central Nervous System (CNS) toxic pontential. The convulsive activity of the quinolones was markedly potentiated by the pretreatment of Fenbufen. In combination with Fenbufen, enoxacin (ENX), norfloxacin (XFLX), and ciprofloxacin (CPFX) provoked convlusions and subsequent death at the intravenous doses of 0.5mg/kg, 10mg/kg, and 40mg/kg, respectively, whereas ofloxacin (OFLX) and pefloxacin (PFLX) did not induce convulsions and death even at a relatively high dose of 100mg/kg iv.

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References

  1. Antimicrob. Agents Chemother. v.33 Structure-epileptogenecity relationship of Quinolones with special reference their interaction with γ-aminobutyric acid receptor sites Akahane,K.;Sekiguchi,M.;Une,T.;Osada,Y.
  2. Goodman and Gilman's The pharmacological basis of therapeutics(7th ed.) Alfred Goodman;Gilman. Louis S, Goodman
  3. Am. J. Med. v.82 Ciprofloxacin; An update on clinical experiance Arcieri,G.E.;Griffith,G.;Gruenwaldt,A.;Heyd,B.D.;Brien,N.;becker R. August
  4. Review of Infectious Diseases v.10 Specifc toxicologic aspects of the quinolones Christ,W.;Lehnert,T.;Ulbrich,B.
  5. Antimicrob. Agents Chemother. v.35 Hippocampal activity in the presence of quinolones and fenbufen in vitro Dimpfel,W.;Spuler,M.;Dalhoff,A.;Hofmann,W.;Schluter,G.
  6. Pharm. Weekbl. Sci. v.8 Fluorinated quinolones, A review of their mode of action, antimicrobial activity, pharmakokinetics and clinical efficacy Janknet,R.
  7. J. Pharmarcol. and Experi. Therap. v.258 no.3 Enhanced entry of ciprofloxacin into the rat central nervous system induced by fenbufen Kohji,N.;Yoshihiro,K.;Nobuhiro,I.;Masakazu,H.;Kikuo,I.
  8. Abstr. 16th Int. Cong. Chemother. Abstr. No. 192 Nozaki,M.;N.Takeda;Tanaka;K.Tsurumi
  9. Proceedings of the 1st International Ciprofloxacin Workshop Toxicology of ciprofloxacin Schluter,G.
  10. Antimicrob. Agents Chemother. v.32 Quinolones, Theophylline and Diclofenac interactions with the gamma-aminobutyric acid receptor Segev,S.;Rehavi,M.;Rubinstein,E.
  11. Antimicrob. Agents Chemother. v.32 Inhibitory effects of Quinolone anibacterial agents on γ-aminobutyric acid binding to receptor sites in rat brain membranes Tsuiji,A.;Sato,H.;Kume,Y.;Tamai,I.;Okeezaki,E.;Nagata,O.;Kato,H.
  12. Antimicrob. Agents Chemother. v.32 Animal model for evaluating the convulsive liability of β-lactam antibiotics Williams,P.D.;Bennett,D.B.;Comereski,C.R.