Toxicological Research

  • 제8권1호
  • /
  • Pages.17-27
  • /
  • 1992
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

A STUDY ON ANTIGENICITY OF GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR(LBD-005) IN MICE AND GUINEA PIGS

  • Park, Jong-Il (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Han, Sang-Seop (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Roh, Jung-Koo (Toxicology Research Center Korea Research Institute of Chemical Technology)
  • 발행 : 1992.06.01
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초록

Antigenicity of Recombinant Granulocyte macrophage colony stimulating factor(LBD-005), a newly developed drug for hematopoietic growth, was investigated in mice and guinea pigs. 1. Mice showed production of antibodies against LBD-005 (100mg/kg) with alumin]m hydroxide gel(alum) as an adjuvant, judged by the heterologous anaphylaxis(PCA) test using rats. On the other hand, antibodies against ovalbumin(OVA) inoculated with alum were definitely detected. 2. In the studies with guinea pigs, both the inoculation of LBD-005 only and of LBD-005 with complete Freund's adjuvant(CFA) as an adjuvant did not produce positive reactions in homologous passive cutaneous anaphylaxis (PCA).

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참고문헌

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