The Korean Journal of Zoology (한국동물학회지)

The Korean Society for Integrative Biology (한국통합생물학회)
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Effects of an Antimetabolite 6-aminonicotinamide on Carbohydrate, Nucleotide and Catecholamine Metabolism in Mouse Brain

항 대사물질 6-aminonicotinamide가 생쥐 뇌의 탄수화물, 뉴클레오티드 및 카테콜라민 대사에 미치는 영향

  • Jung, Heon-Keun (Department of Clinical Paholosy, Toelon Junior College, Taejon 302-210, Koreo, Department of Agrobiology Dongsuk Uniueniu, seoul 100-715) ;
  • Park, In-Kook (Department of Clinical Paholosy, Toelon Junior College, Taejon 302-210, Koreo, Department of Agrobiology Dongsuk Uniueniu, seoul 100-715)
  • Published : 1992.01.01
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Abstract

The effects of an antimetabolite, 6-aminonicotinamide (6-AU) on the levels of glucose, glycogen, catechoamines and mucleotides in mice brain were investigated. The level of glucose in the blood starts increasing from 3 h after administration of 6-AU while those in the brain tissue start increasing from 9 h after administration of 6-AN. The concentration of brain glvcogen remained unchanged at all time points except 11h. The level of epinephrine in the brain was found to reach maximum value at initial 3 h following 6-AU administration, after urhich it started dec$\ulcorner$easing si역서cantle. The Brvel of brain norepinephrine remained virtually unchanged before 24 h time point at which it starts decreasing significantly. ATP, CTP, UMP and UTP levels were significantly reduced but AMP and CMP levels urere not affected.

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