이엽식 고분자판막의 수력학적 특성평가 및 동물실험

In-vitro Evaluation of a Bileaflet Polymer Valve and Preliminary Animal Tests


초록

In order to use a low cost polymer valve in our total artificial heart and ventricular assist device, we have developed a slit-type bileaflet polymer valve[BPV 1. The aim of this study is to determine the hydrodynamic effectiveness of the newly-designed BPV and its feasibility for temporary use in the blood pumps. For hydrodynamic comparison, we investigated in-vitro the pressure drop across the valve, the leakage volume, the flow rate and the flow pattern of the BPV, two mechanical valves and a trileaflet polymer valve. We employed the ventriculo-pulmonary bypassing method for in-vivo tests of the BPV's together vilh our electrohydraulic left venIn ricular assist device in mongrel dogs. The BPV showed adquate gydrodynamic performances and in the preliminary animal bests, there was no xvi dence of thrombus formation on the valve leaflets and around the struts. Detailed results obtained from the animal tests will be separately reported. This report involves the design criteria, fabrication and hydrodynamic charateristics of she BPV, and the basic merits and demerits of the valve are dis- cussed from the hydrodynamic point of view.

키워드

참고문헌

  1. Ann. Surg. v.154 Mitral replacement clinical experience with a ball-valve prosthesis A.Starr;M.L.Edwards
  2. Scand. J. of Thoracic Card. Surg. v.3 A new tilting disc valve prosthesis V.O.Bjork
  3. J. Thorac Cardiovasc Surg. v.78 Ten years experience with the Bjork-Shiley tilting disc valve V.O.Bjork;A.Henze
  4. Encyclopedia of medical devices and instrumetation Heart valve prosthses H.Shim;J.A.Lenker
  5. The Bjork-Shiley aortic prosthesis : Flow characteristics, thrombus formation and tissue overgrowth, Circulation v.58 A.P.Yoganathan;W.H.Corcoran;E.C.Harrison;J.R.Cari
  6. Artificial Organs v.V14 no.5 Quantification of perivalvular thrombus formation in blood pumps by coordinate mapping G.M.Pantalos;S.D.Everett;S.F.Mohammad;G.L.Burns;K.A.Solen;L.O.Reynolds;D.B.Olsen
  7. J. Cardiovasc Surg v.30 Thirteen years evaluation of the Bjork-Shiley isolated mitral valve prosthesis : The Wessex experience I.Th.Fessatidis;K.E.Vassiliadis;J.L.Monro;J.K.Ross;D.F.Shore;P.J.drury
  8. J. Cardiovasc Surg v.30 Prospective randomized study of St Jude Medical versus Bjork-Shiley or Starr-Edwards 6120valve prostheses in the mitral position Ph.Mikaeloff;O.Jegaden;M.ferrini;J.CollMazzei;J.Y.Bonnefoy;A.Rumolo
  9. J. Thorac. Cardiovasc. Surg. v.V58 Biological factors affecting long-term results of valvular heterografts A.Carpentier;C.G.Lamaigre;L.Robert;S.Carpentier;C.Dubost
  10. J. Thorac. Cardiovasc. Surg. v.62 the flexible stent : A new concept in the fabrication of tissue valve prostheses R.L.Reis;W.D.Hankock;J.W.Yarbrough;D.L.Glancy;A.G.Morrow
  11. L. Thorac. Cardiovasc. Surg. v.73 Hewart valve replacement with the Ionescu-Shiley perticardial xenograft M.I.Ionescu;A.p.Tandon;D.A.S.Mary;A.Abid
  12. J. Biomechanics v.V22 no.6;7 Vitro flow dynamics of four prosthetic aortic valves : A comparative analysis D.D.Hanle;E.C.Harrison;A.P.Yoganatan;D.T.Allen;W.H.Corcoran
  13. Cardiovasc. Implants v.V15 no.5 Calcification modelig in artificial heart valves A.C.Fisher;G.M.Bernacca;T.G.Mackay;W.R.Dimitri;R.Wilkinson;D.J.Wheatley
  14. J. of Clinical Eng. v.14 vitro engineering testing of prosthetic cardiac valves Yoser A.M.Haggag
  15. J. Thorac Cardiovasc Surg. v.86 Physical analysis of the Bjork-Shiley prosthetic valve sound F.Schondube;H.Keusen;B.J.Messmer
  16. ASAIO Trnas v.V57 no.3 Advances in design principle and fluid dynamics of a flexible polymeric heart valve J.Jansen;S.Willeke;B.Reiners;P.Harbott;H.Reul;H.B.Lo;S.Dabritz;C.Rosenbaum;A.Bitter;K.Ziehe;G.Rau;B.J.Messmer
  17. Trans. Int. Soc. Art. Organs v.2 Design and in vitro evaluation of a new shell-type artificial heart valve H.Reul;H.Muller;W.Tillman
  18. Trans. Am. Soc. Artif. Intern. Organs v.24 A single-leaflet mitral valve : its design, development and evaluation in long-term animal trials W.G.williams;B.J.Belhouse;F.H.Bellhouse;W.S.Haworth;G.Kent;R.W.H.Lewis
  19. The development of a prosthetic heart valve utilizing a rigid housing and a flexible butterflywing leaflet V.L.Gott;R.L.Daggett;R.J.Botham;D.E.Koepke;W.C.Zarnstorff;W.P.Young
  20. The Int. J. of Art. Organ v.13 Development of a new inflow valve for a 20cc semisoft ventricle : preliminary results E.G.Wijsmuller;L.S.Yu;B.Yuan;N.D.Bishop;W.G.Kolff
  21. Trans. of the ASME v.102 The design, fabrication and evaluation of a trileaflet prosthetic heart valve G.E.Chetta;J.R.Lloyd
  22. Trans. Int. Soc. Art Organs v.6 Hexyn trileafley valve : Application to temporary blood pumps R.Kiraly;R.Yozu;D.Hillegass;H.Harasaki;S.Murabayashi;J.Snow;Y.Nose
  23. J. of Biomech. Eng. v.102 The design, fabrication and evaluation of a trileaflet prosthetic heart valve G.E.Chetta;J.R.Lloyd
  24. ASAIO Trans v.34 A newly designed jellifish valve for an artificial heart blood pump K.Imachi;I.Fujimasa(et al.)
  25. ASAIO Trans v.37 Blood compatibility of the jellifish valve without anticoagulant K.Imachi;K.Mabuchi;T.Chinzei;Y.Abe;K.Imanishi;M.suzukawa;T.Yonezawa;A.Kouno;T.Ono;H.Nozawa;K.Atsumi;I.Fujimasa
  26. J. of KOSOMBE v.11 no.2 Viscoelastic fluid flow in a sudden expansion circular channel as a model for the blood flow experiments B.C.Pak;C.S.Kim
  27. Biomat. Med. Der. Art. Organs v.1 Stress analysis of normal human aortic valve leaflets during diastole P.K.Chong;D.S.Wieting;N.Hwang
  28. 대한흉부외과학회지 v.20 no.3 Development and animal tests of artificial heart valves J.Y.Lee(et al.)
  29. The Seoul J. of Medicine v.32 no.1 Development of polymer prosthetic heart valve : fabrication and in vitro test I.Y.Kim;J.W.Kim;D.Y.Jung;C.S.Kim;B.G.Min
  30. J. Biomechanics v.V24 no.8 A numerical analysis of the backflow between the leaflets of a Jude medical cardiac valve prosthesis T.H.Reif
  31. ASAIO Trans. v.V37 Mean velocities and reynolds stresses within regurgitant jets produced by tilting disc valves J.T.Baldwin;J.M.tarbell;S.Deutch;D.B.Geselowitz