In Vitro Evaluation of Reused Hollow Fiber Dialyzers

  • Kim, Y.H. (Cardiovascular Fluid Dynamics Laboratory School of Chemical Engineering Georgia Institute of Technology)
  • Published : 1992.09.01

Abstract

Air pressure decay (APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those reused in patients several times. C-DAK 4000 (Cordis Dow) and CF 15-11 (Baxter Travenol) reused dialyzers obtained (rom the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAK dialyzers had a larger APD($11.70{\pm}1.32$mmHg/min) compared to CF dialyzers($4.32{\pm}0.55$mmHg/min) (p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHg/min)on the reused dialyzers(2 out of 40 CF and 5 out 26 C DAK) were attributed to the possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD Is a more son sitive test than UFR test to evaluate the integrity of the fibers.

Keywords

References

  1. A Special Report : National Kidney Foundation Report on Dialyzer Reuse v.11 National Kidney Foundation
  2. Artif. Organs v.6 Severe Reactions to Cuprophan Capillary Dialyzers Popli,S.;Ing,T.S.;Daugirdas,J.T.;Kheirbek,A.O.;Viol,G.W.;Vilbar,R.M.;Gandhi,V.C.
  3. Transactions ASAIO v.28 Dialyzer Reuse in a Large Dialysis Program Luehmann,D.;Hirsch,D.;Carlson,G.;Constantine,E.;Keshaviah,D.
  4. Kidney International v.19 Multiple Use of Dialyzers : Safety and Efficacy Kant,K.S.;Pollak,V.E.;Cathey,M.;Goetz,D.;Berlin R.;Eydel D.F.;Tessel,J.;Hall,R.
  5. JAMA v.246 Effect of Multiple Use of Dialyzer on Hepatitis B incidence in Patients and Staff Favero,M.S.;Deane,N.;Leger,R.J.;Josin,A.E.
  6. Br. Med. J. v.285 Anaphylactoid Reactions due to Hemodialysis, or Membrane Plasma Separator Nicholls,A.J.;Platts,M.M.
  7. Nephron v.13 Solute Transport in Reused Hollow Fiber Artificial Kidney Raja,R.M.
  8. Trans. Am. Soc. Artif. Intern. Organs v.19 Detrimental Effects of Air Rinsing on Dialysis Membranes Bass,O.E.;Nothum,R.J.;Nolph,K.D.;Maher,J.F.