대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제13권2호
  • /
  • Pages.155-164
  • /
  • 1992
  • /
  • 1229-0807(pISSN)
  • /
  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지

펩티드성분을 함유하는 블록공중합체막의 세포접착성

Attachment of Fibroblast Cells on the Block Copdymer Membrane containing Peptide Segments

  • 강인규 (경북대학교 고분자공학과) ;
  • 강신성 (경북대학교 생물학과) ;
  • 임학상 (경북대학교 고분자공학과)
  • Kang, Inn-Kyu (Dept. of Polymer Science, Kyungpook National University) ;
  • Kang, Shin-Sung (Dept. of Biology, Kyungpook National University) ;
  • Lim, Hak-Sang (Dept. of Polymer Science, Kyungpook National University)
  • 발행 : 1992.06.01
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초록

Attachment and growth of mouse flbroblast cells on block copolypeptides were studied in the pres once or absence of serum proteins. Cells are rapidly attached to she polymer surface within 30 min regardless of substrate in the presence of serum. The number of flbroblast cells attached on the poly mer surface coated by collagen was larger than thats on the bare surface. Attachment of cells Is as a whole suppressed to a low level by the addltion of sodium azide in the absence of serum. Thls suE gests that the active attachment of cells requires the biological metabolism taking place on polymer substrates. In the presence of serum protein, flbroblast cells are more rapidly grown on the bolck co polymer consisting of poly(T-benzyl L-glutamate) (PBLG) and polyoxypropylene(POP) than on other block copolymers. These results were in agreement wish the data obatlned by an Inverted ml croscope.

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