Archives of Pharmacal Research
- Volume 15 Issue 4
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- Pages.298-303
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- 1992
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effects of Barbiturates on the Rotational Relaxation Time of 1, 6-Diphenyl-1, 3, 5-hexatriene in Native and Model Membranes
- Chung, Yong-Za (Department of Biochemistry, Kyungsung University) ;
-
Shin, Yong-Hee
(Pharmaceutics, Colleg of Pharmacy, Kyungsung University)
;
- Choi, Chang-Hwa (Department of Neurosurgery, Pusan University) ;
- Park, Hyung-Sook (Fundamental Nursing, College of Medicine, Pusan National University) ;
- Koh, Yeong-Sim (Department of Chemistry, College of Natural Sciences, Pusan National University) ;
- Yun, Il (Dental Pharmacology and Biophysics, College of Dentistry, Pusan National Unversity)
- Published : 1992.12.01
Abstract
Synaptosomal plasma membrane vesicles (SPMV) were isolated from fresh bovine cerebral cortex. The effects of barbiturates on the rotational relaxation time of 1.6-diphenyl-1, 3, 5-hexatriene (DPH) in intact SPMV and model membranes of total lipids (SPMVTL) and phosphlipids (SPMVPL) extracted from SPMV were examined. Barbiturates decreased the rotational relaxation time of DPH in intact SPMV in a dose-dependent manner. In contrast, they did not affect the rotational relaxation time of DPH in SPMVTL and even dose-dependently increased the rotational relaxation time of DPH in SPMVPL.