Archives of Pharmacal Research
- Volume 15 Issue 4
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- Pages.275-282
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- 1992
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Brazilin Inhibits Mitogen Inducedd Cell Proliferation Despite of Augmentation of T Cell Growth Factor (TCGF) Production and Expression of IL-2 Receptors
-
Moon, Chang-Kiu
(College of Pharmacy, Seoul National University)
;
- Mock, Myung-Soo (College of Pharmacy, Seoul National University) ;
- Yang, Kyung-Mee (College of Pharmacy, Seoul National University) ;
- Lim, Cheol-Hong (College of Pharmacy, Seoul National University) ;
- Kim, Kang-Seok (College of Pharmacy, Seoul National University) ;
-
Chung, Jin-Ho
(College of Pharmacy, Seoul National University)
;
-
Moon, Chang-Hyun
(School of Medicine, Ajou University)
- Published : 1992.12.01
Abstract
The present work was designed to investigate the effects of barzilin on ConAinducedd TCGF release, responsiveness to standardd IL-2, and mitogens-induced proliferation of splenocyte when administered intraperitoneally to 8 week-old C57BL/6 mice for 2 consecutive days. Immunological tests were performed 72 hours after the treatment of brailin. The administration of 50 mg/kg brazilin caused a noticeable increase in TCGF release and responsiveness to standard II-2 but inhibited mitogens-induced proliferation of splenocyte. These results that brazilin is able to modular immunological functions despite of its inhibitory effect on mitogen induced cell proliferation.