Synthetic $\beta$-Lactam Antibiotics VI. Antibacterial Activity of Some 7$\beta$[-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(pyrrolidinium) methylcephalosporins

In the preceding paper, we reported the synthessis and biological properties of cephalosporins having quinoliniumthiomethyls at the C-3 position and demonstrated that quinoliniumthiomethylcephalosporins exhibited an extended antibacterial spectrum including antipseudomonal activity, especially strong antiGram-positive activity. With the aim of elaboration to optimize the antibacterial potency of the quaternary ammonium cephalosporins, we have studied the modification of substituents in the pyrrolidine ring of cefepime 1 which is characterized by its potent activity.