Archives of Pharmacal Research
- Volume 15 Issue 2
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- Pages.184-186
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- 1992
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Malonyl Amino Acids and Their Esters as Psychoactive Agents I
- Jain, Dilip (Department of Pharmaceutical Sciences) ;
- Tripathi, Meena (Department of Pharmaceutical Sciences) ;
- Kohli, D.V. (Department of Pharmaceutical Sciences) ;
- Uppadhyay, R.K. (Department of Pharmaceutical Sciences)
- Published : 1992.06.01
Abstract
Malonic acid amides were synthesized using different amino acids and their esters. THe synthesized compounds were evaluated for their sedative activity on rats. Potentiating effect of all the compounds on pentobarbitone induced sleep on rats was observed. Plasma protein binding studies were also carried out and it was observed that the synthesized compounds have low plasma protein binding as compared to barbiturates.