Journal of Ginseng Research
- Volume 16 Issue 3
- /
- Pages.175-182
- /
- 1992
- /
- 1226-8453(pISSN)
- /
- 2093-4947(eISSN)
The Antihypertensive Effect of Red Ginseng Saponin and the Endothelium-Derived Vascular Relaxation
홍삼 사포닌의 혈압강하작용과 내피의존성 혈관 이완에 미치는 효과
Abstract
Intravenous administration of saponin from the root of Panax ginseng (red ginseng) lowered the blood pressure in a dose-dependent manner (10~100 mg/kg B.W) in anesthetized rats. Therefore, experiments were designed to study whether this lowering of blood pressure is associated with the release of endothelium-derived relaxing factor. Rings of thoracic aorta with and without endothelium were suspended for the measurement of isometric tension in organ chamber. All experiments were performed in the presence of indomethacin (10-5 M). Ginseng saponin (10-5~3