Journal of Pharmaceutical Investigation
- Volume 22 Issue 4
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- Pages.317-321
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
HPLC Determination of Diltiazem and Deacetyldiltiazem in Rat Plasma
HPLC를 이용한 랫트 혈장중의 딜타아젬 및 데아세틸딜티아젬의 정량
- Lee, Yong-Hee (College of Pharmacy, Seoul National University) ;
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
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Lee, Min-Hwa
(College of Pharmacy, Seoul National University) ;
- Kim, Shin-Keun (College of Pharmacy, Seoul National University)
- Published : 1992.12.20
Abstract
A high-performance liquid chromatographic (HPLC) method was developed for the determination of diltiazem (DTZ) and its major metabolite, deacetyldiltiazem (DAD), in rat plasma. DTZ, DAD and imipramine, the internal standard, were selectively fractionated from plasma on a
Keywords
- HPLC;
- diltiazem (DTZ);
- deacetyldiltiazem (DAD);
- pH;
- mobile phase;
- sensitivity;
- inter-day;
- intra-day variation;
- recovery