Journal of Pharmaceutical Investigation
- 제22권4호
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- Pages.281-287
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
오메프라졸의 제제화 및 평가
Stability and Dissolution Enhancement of Omeprazole by Pharmacentical Formulation
- Jee, Ung-Kil (College of Pharmacy, Chungnam National University) ;
- Lee, Gye-Won (College of Pharmacy, Chungnam National University) ;
- Jeon, Un-Jong (College of Pharmacy, Chungnam National University)
- 발행 : 1992.12.20
초록
Omeprazole (OMZ) is very unstable in acidic solution, which selectively inhibit the release of the gastric juice in the gastric mucosa, In order to stabilize (OMZ) in oral solid dosage form, the enteric-coated microcapsules and compression-coated OMZ tablets containing lysine or arginine as stabilizer were prepared and their dissolution and stability test were performed. The haif life of OMZ microcapsules containing arginine was 194 days at
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