Journal of Pharmaceutical Investigation
- 제22권3호spc1호
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- Pages.65-76
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Superoxide Dismutase Mimetic Activity of Cu(II)-Salicylic Acid Analogs
초록
The superoxide dismutase (SOD)-mimetic activities of copper complexes of a series of salicylic acid (SA) analogs were tested and compared to the activity of bovine erythrocyte SOD using ferricytochrome c reduction assay. Stability constants of copper complexes were measured potentiometrically using SCOGS2 program. In the presence of 10 g/l albumin, all the copper complexes lost their SOD mimetic activities. Multiple regression analysis was employed for the statistical comparisons between the SOD mimetic activity and their physicochemical properties. Correlation exists for the SOD mimetic activity and steric parameter
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