Journal of Pharmaceutical Investigation
- Volume 22 Issue 3
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- Pages.197-204
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Simultaneous Determination of Haloperidol and Its Metabolite, Reduced Haloperidol, in Plasma by Gas Chromatography Using Nitrogen Phosphorous Selective Detection
Gas Chromatography-Nitrogen Phosphorous Selective Detection을 이용한 혈장중 Haloperidol 및 대사체인 Reduced Haloperidol의 동시정량
- Park, Kyoung-Ho (Department of Pharmacy, Seoul National University Hospital) ;
- Lee, Min-Hwa (Department of Pharmacy, Seoul National University Hospital, College of Pharmacy, Seoul National University) ;
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
- Lee, Myung-Gull (College of Pharmacy, Seoul National University) ;
- Park, Jong-Sei (Doping Control Center, Korea Institute of Science and Technology)
- 박경호 (서울대학교병원 약제부) ;
- 이민화 (서울대학교병원 약제부, 서울대학교 약학대학) ;
- 심창구 (서울대학교 약학대학) ;
- 이명걸 (서울대학교 약학대학) ;
- 박종세 (한국도핑콘트롤센터)
- Published : 1992.09.20
Abstract
A gas chromatographic method using nitrogen phosphorous selective detection was developed for simultaneous determination of haloperidol and its metabolite, reduced haloperidol, in human plasma. Combelen was used as internal standard, The method involved extraction and trimethylsilylation followed by the injection of
Keywords
- Haloperidol;
- Reduced haloperidol;
- Gas chromatography;
- Nitrogen-phosphorous sensitive detector;
- Plasma;
- Combelen;
- Trimethylsilylation