Journal of Pharmaceutical Investigation
- 제22권2호
- /
- Pages.97-104
- /
- 1992
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
흡수촉진제인 지방산염이 토끼의 비강점막 균질액에서 인슐린 분해에 미치는 영향
Effect of Fatty Acid Salts on Proteolysis of Insulin in the Nasal Tissue Homogenates of Rabbits
-
Han, Kun
(College of Pharmacy, Chungbuk National University) ;
- Cha, Cheol-Hee (College of Pharmacy, Chungbuk National University) ;
-
Chung, Youn-Bok
(College of Pharmacy, Chungbuk National University) ;
-
Park, Cheong-Sook
(College of Pharmacy, Chungbuk National University)
- 발행 : 1992.06.20
초록
The purpose of this study was (i) to determine whether protease inhibition by medium chain fatty acids such as sodium caprate, sodium caprylate and sodium laurate led to suppression of insulin proteolysis over a range of insulin concentrations and (ii) elucidate preventing effect of the enhancers on molecular self-association of insulin in pH 7.4 phosphate buffer isotonic solution. To this end, the rate of insulin proteolysis in nasal tissue supernatants of the albino rabbits was determined in the presence of
키워드